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Infectious mononucleosis -- known popularly as "mono" or "the kissing disease" -- has been recognized for more than a century. An estimated 90 percent of mononucleosis cases are caused by the Epstein-Barr virus (EBV), a member of the herpes virus group. Most of the remaining cases are caused by certain other herpes viruses, particularly cytomegalo virus. This fact sheet focuses on mononucleosis ....

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.... infects and reproduces in the salivary glands. It also infects white blood cells called B cells. Direct contact with virus-infected saliva, such as through kissing, can transmit the virus and result in mononucleosis. Someone with mononucleosis, however, does not need to be isolated. Household members or college roommates have only a slight risk of being infected unless they come into direct contact with the patient's saliva. A person is infectious several days ....

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